Table 2. The effect of alanine substitutions of TP5 on binding HLA-DR.
Substitutions | Binding energy (kcal/mol) | Key residues |
RKDVY | −8.99 | E11, N62 |
AKDVY | −6.31 | E11, N62 |
RADVY | −7.27 | |
RKAVY | −7.18 | N62 |
RKDAY | −6.11 | |
RKDVA | −7.09 | N62 |
Substitutions | Binding energy (kcal/mol) | Key residues |
RKDVY | −8.99 | E11, N62 |
AKDVY | −6.31 | E11, N62 |
RADVY | −7.27 | |
RKAVY | −7.18 | N62 |
RKDAY | −6.11 | |
RKDVA | −7.09 | N62 |