Table 2. The dopac/dopamine metabolic ratios.
Brain areas | Control | FC | FC+Cloz | FC+Ket | FC+Ket+Cloz | |||||
Median | Range | Median | Range | Median | Range | Median | Range | Median | Range | |
ACC | 1.35 | 2.19 | 0.79 | 49.95 | 0.93 | 1.79 | 0.64 | 0.51 | 0.82* | 2.98 |
Nacc | 0.19 | 0.16 | 0.45# | 29.08 | 0.18& | 0.04 | 0.20& | 0.05 | 0.21& | 0.14 |
CEA | 0.20 | 0.17 | 0.19 | 13.28 | 0.20 | 0.35 | 0.09& | 0.05 | 0.11+ | 0.10 |
p<0.01 from FC+Ket
p<0.01 from control
p<0.01 from FC
p = 0.056 from FC
ACC = anterior cingulate, CEA = central amygdala nucleus, Cloz = clozapine, FC = fear conditioned, Ket = ketamine, Nacc = nucleus accumbens