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. 1997 Aug 25;138(4):799–810. doi: 10.1083/jcb.138.4.799

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The BTBIVR region is required for kelch's ring canal organizer activity. Actin filaments in wild-type ring canals (A) are neatly organized in the ring canal inner rim, while actin filaments in kel^DE1 ring canals (B) are disorganized and extend into the lumen of the ring canal. Myc:ORF1 localized to kel^DE1 mutant ring canals (C) and organized the inner rim actin (D). Myc:ΔNORF1 produced from the myc:ΔNORF1 15-2 line also localized to kel^DE1 mutant ring canals (E) and organized the actin filaments in the inner rim (F). Myc:KREP also localized to kel^DE1 mutant ring canals (G); however, it was unable to rescue ring canal morphology (H).