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Kelch is an oligomeric ring canal actin organizer. (A) Summary of domain functions. (B) A proposed model for how kelch organizes the ring canal actin filaments. Through the KREP domain (R), kelch localizes to the ring canal possibly by binding to an unknown ring canal component (?). It likely binds to another component (possibly the actin filaments) also through the KREP domain. The protein forms cross-links through the BTBIVR region of the protein.
