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. 1997 Aug 25;138(4):811–820. doi: 10.1083/jcb.138.4.811

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Gelsolin-modulated PLC_β1 activity through PIP₂ binding. (A) Gelsolin NH₂-terminal domains (GS1-406) containing none or between one to three PIP₂-binding sites. Gelsolin segments 1, 2 and 3 are as defined in reference 17. *PIP₂-binding sites that have been localized. ?, suspected PIP₂-binding site that has not yet been located precisely. (B) Effects of gelsolin domains on PLC_β1. (C) Effect of P2 on PLC_β1. In B and C, enzyme activity was assayed for 1 min and expressed as percent of control in the absence of exogenous protein.

Gelsolin-modulated PLC_β1 activity through PIP₂ binding. (A) Gelsolin NH₂-terminal domains (GS1-406) containing none or between one to three PIP₂-binding sites. Gelsolin segments 1, 2 and 3 are as defined in reference 17. *PIP₂-binding sites that have been localized. ?, suspected PIP₂-binding site that has not yet been located precisely. (B) Effects of gelsolin domains on PLC_β1. (C) Effect of P2 on PLC_β1. In B and C, enzyme activity was assayed for 1 min and expressed as percent of control in the absence of exogenous protein.