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. 1968 Aug 1;128(2):309–323. doi: 10.1084/jem.128.2.309

PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER

Richard K Root 1, Sheldon M Wolff 1
PMCID: PMC2138518  PMID: 4873023

Abstract

When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state of febrile tolerance when repeatedly administered. The second pyrogen, demonstrable during fever in donor rabbits, appears to be similar to endogenous pyrogen described in other experimental fevers. It is postulated that the formation of antigen-antibody complexes constitutes an important initial phase of the febrile reaction in this type of immune fever.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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