Figure 2.

Light micrographs of ventral roots, dorsal roots and spinal cord from NF-H-transgenic mice. Transverse sections of L5 ventral roots, dorsal roots, and spinal cord from normal mice (A, B, and C), NF-H⁴⁴ mice (D, E, and F), and NF-H⁴³ mice (G, H, and I) (12-mo-old). Mice overexpressing human NF-H⁴³ showed more prominent neurofilamentous accumulations in spinal motor neurons (I) than mice overexpressing NF-H⁴⁴ (F). The axonal atrophy in ventral and dorsal roots is also more severe in mice expressing NF-H⁴³ (G and H) than in those expressing NF-H⁴⁴ (D and E). The arrows point to neurofilament accumulations. (I, Bar = 10 μm.)