Table 5.

Therapeutic effects of desoxyepothilone B, paclitaxel, adriamycin, and camptothecin in nude mice bearing MDR human MCF-7/Adr tumor

Drug	Dose, mg/kg	Average body weight change, g					Average tumor size, T/C				Toxicity death	n
		Day 8	11	13	15	17	Day 11	13	15	17
Control	0	25.0	+2.0	+2.6	+3.1	+3.7	1.00	1.00	1.00	1.00	0/8	8
dEpoB	35	25.0	0.3	+0.7	+0.6	+0.8	0.31**	0.27***	0.30***	0.34*	0/8	8
Paclitaxel	6	25.3	+1.7	+1.8	+0.8	+0.9	0.57	0.66	0.85	0.90	0/7	7
	12	24.5	+0.7	−1.3	−2.4	0	0.50	0.51	0.32	0.40	3/7	7†
Adriamycin	2	25.6	+0.2	−0.4	−0.6	−0.4	0.70	0.68	0.84	0.78	0/8	8
	3	24.6	+0.5	−1.3	−3.2	−1.6	0.66	0.83	0.57	0.53	3/6	6†
Campothecin	1.5	24.4	+1.1	+0.9	+1.7	+1.4	1.08	0.72	0.61	0.72	0/8	8
	3	24.5	−0.6	−0.4	−0.8	−0.9	0.95	0.76	0.61	0.43*	0/6	6

MCF-7/Adr cell 3 × 10⁶/mouse was implanted s.c. on day 0. Every other day i.p. treatments were given on days 8, 10, 12, 14, and 16. The average tumor size of control group on days 11, 13, 15, and 17 was 392 ± 84, 916 ± 210, 1,499 ± 346, and 2,373 ± 537 mm³, respectively (mean ± SEM). 

*P < 0.05, **P < 0.01, ***P < 0.005. 

^†P values were not shown because of toxic lethality.