Figure 1.

Density gradient centrifugation of AChE extracted from muscle in control subject (A) and EAD patients 1, 4, 5, and 6 (B–E). Mutations in each case are indicated. A and G denote asymmetric and globular species. In each patient extract, the heteromeric A₁₂ and A₈ species are absent and the composite G₄/A₄ peak is replaced by a single mutant ≈10.5S peak. (M, mutant peak.)