Figure 3.

Alignment of the amino acid sequences of human, rat (14), partial mouse (14), and Torpedo (13) ColQ and truncation mutations in the patients. Gaps are inserted for alignment. The amino acid sequence encoded by the alternatively transcribed exon 1A also is shown. Closed arrowheads point to the first amino acid deleted by the truncation mutations. Dashes show identical amino acids. Secretion signal peptides are italicized for all species. Collagen domains consisting of GXY triplets are underlined. A black bar indicates the PRAD. Hatched bars indicate heparan sulfate proteoglycan binding domains. Open arrowheads show essential cysteines. The right column indicates codon numbers.