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. 1997 Apr 21;137(2):387–398. doi: 10.1083/jcb.137.2.387

Figure 6.

Figure 6

Figure 6

Figure 6

Confocal images of COS-7 cells expressing mutant Tiam1 proteins. Confocal laser scanning microscopic images of COS-7 cells expressing C580 Tiam1 (A), MS-C580 Tiam1 (B), full-length Tiam1 (FL1591) (C), full-length Tiam1 with a deletion in the NH2-terminal PH domain (FL-ΔPHn) (D), and FL-ΔPHn containing a Src myristoylation signal at the NH2 terminus (MS-FL-ΔPHn) (E). The insert in E is a higher magnification of the framed region showing the vesicle-like structures that are surrounded by the MS-FL-ΔPHn Tiam1 protein. Indicated in blue is the myristoylation signal from c-Src (MS), containing the NH2-terminal 20 amino acids. In the merged images, Tiam1 is shown in green and F-actin in red. Magnification is 200×. Bar, 40 μm.

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