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. 1997 Apr 21;137(2):291–303. doi: 10.1083/jcb.137.2.291

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Association of Hrb57A with the 93D locus in situ. The RNA at the 93D locus in the nuclei of fixed embryos was detected by hybridization with the Fl-P2 oligonucleotide (left column) and the Hrb57A protein by mAb Q18 followed by a Cy3-coupled secondary antibody (center column). The superposition of both signals in an RGB image generates a yellow color where 93D and the protein are colocalized (right column). (A) A group of interphase nuclei from a nonstressed embryo. Overlay of 15 optical sections separated by 0.35 μm. (B) Higher magnification of a subregion from the field shown in A demonstrating the precise overlap of the 93D signals with some of the Hrb57A accumulations. (C) A group of interphase nuclei from an embryo that had been heat shocked at 37°C for 60 min before fixation. The restriction of Hrb57A to the 93D locus is evident.