Table III.
Summary of the Distribution of CK19 in Epithelia in Culture and In Vivo
| Organ/Tissue | Species | Image | ||
|---|---|---|---|---|
| MDCK (kidney, distal, or collect. tub.) | Dog | Apical, continuous‡ | ||
| MCF-10A (normal mammary epith.) | Human | Apical, continuous* | ||
| CACO-2 (colon carcinoma, differentiates in tissue culture) | Human | Apical, continuous* | ||
| Stomach (surface and glandular epithelium) | Human | Apical, continuous* | ||
| Lung (bronchiolar epithelium) | Human | Apical, continuous* | ||
| Breast (duct epithelium) | Human | Apical, continuous* | ||
| Kidney (collecting tubule) | Rat | Apical, continuous* | ||
| Kidney (S-shaped body) | Human fetal | Apical, continuous§ | ||
| Small intestine (epithelium on villus) | Rat, newborn | Apical, continuous* | ||
| Small intestine (epithelium on villus) | Mouse, adult | Apical, continuous* | ||
| Thyroid | Human | Apical/lateral, heterogeneous‖ | ||
| Lung (intrapulmonary bronchus) | Human | Apical cytoplasm, discontinuous* | ||
| Small intestine (epithelium of villus) | Rat | Apical cytoplasm, discontinuous* | ||
| Small intestine (deep epith. of crypts) | Rat | Negative* | ||
| Liver (hepatocytes) | Rat/human | Negative* | ||
| Kidney (proximal tubule) | Rat/human | Negative* | ||
| Lung carcinoma | Human | Negative* | ||
| Stomach carcinoma | Human | Negative* | ||
| Breast carcinoma | Human | Negative* |
*
Antibodies used in these experiments: A53-B/A2 and RCK108 mAbs and anti-53-kD MDCK protein polyclonal antibody. “Discontinuous” refers to a broad distribution of CK19 in the apical cytoplasm, below the terminal web.