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. 1997 Oct 20;139(2):507–515. doi: 10.1083/jcb.139.2.507

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Sequence analysis of ALP isoforms. (A) Amino acids 5–80 of ALP encode a consensus PDZ domain. Alignment of ALP with PDZ domains from CLP-36, PSD95, α1-syntrophin, (α1syn), nNOS, and INAD. Histidine 62 of ALP is marked with an asterisk and leucine 78 with a pound sign. (B) Predicted sequences of rat ALP (GenBank/EMBL/DDBJ accession no. AF002281) and human ALP (hALP) are aligned with two homologous proteins, CLP-36 and RIL. (C) An alternative ALP isoform is expressed in the heart. Schematic model shows the domain structure of ALP and the divergence of ALP between skeletal muscle (hALP_SK; accession no. AF002280) and heart (hALP_H; accession no. AF002282). The alignment shows that the central region of ALP is different between skeletal muscle and heart. The accession numbers for ESTs used to construct hALP_H are F12229, R20192, AA147575, AA211287, and D56502. The accession numbers for ESTs encoding the skeletal muscle–specific splice for hALP_sk are Z28845, Z19288, and Z28703.

Sequence analysis of ALP isoforms. (A) Amino acids 5–80 of ALP encode a consensus PDZ domain. Alignment of ALP with PDZ domains from CLP-36, PSD95, α1-syntrophin, (α1syn), nNOS, and INAD. Histidine 62 of ALP is marked with an asterisk and leucine 78 with a pound sign. (B) Predicted sequences of rat ALP (GenBank/EMBL/DDBJ accession no. AF002281) and human ALP (hALP) are aligned with two homologous proteins, CLP-36 and RIL. (C) An alternative ALP isoform is expressed in the heart. Schematic model shows the domain structure of ALP and the divergence of ALP between skeletal muscle (hALP_SK; accession no. AF002280) and heart (hALP_H; accession no. AF002282). The alignment shows that the central region of ALP is different between skeletal muscle and heart. The accession numbers for ESTs used to construct hALP_H are F12229, R20192, AA147575, AA211287, and D56502. The accession numbers for ESTs encoding the skeletal muscle–specific splice for hALP_sk are Z28845, Z19288, and Z28703.