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. 1997 Oct 20;139(2):485–495. doi: 10.1083/jcb.139.2.485

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Overexpression of PS-2 proteins in HeLa cells leads to overt changes in nuclear morphology. HeLa cells were transfected with pPS-2+Myc (A–C), pPS-2(268aa)+Myc (D–F), or pKv1.4+Myc (G–I). (A, D, and G) Anti-myc staining of cells 24 h after transfection. The center panels are the corresponding DNA images of the cells revealed by DAPI staining, and the right panels are the phase contrast images of the same cells. Please note that the majority of cells expressing high levels of PS-2 have dismorphic nuclei. In some of these cells, the nuclei are highly condensed with rounded-up and shrunken cytoplasms (arrowheads).