Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1997 Oct 6;139(1):129–144. doi: 10.1083/jcb.139.1.129

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Effect of exercise on muscles. (A) LacZ and NADH activity present on frozen sections of soleus and EDL from 5-mo-old Des +/− and Des −/− mice. Control, non-exercised mice; Exercise, 5 d of exercise. Recovery, exercise plus 5 d recovery. Note the strong expression of β-galactosidase (X-gal), NADH in the soleus (Sol) and EDL of exercise mice. (B) Frozen sections of the gastrocnemius muscles of Des−/− mice (Gas −/−) after 7 and 21 d of regeneration after injection of cardiotoxin. Sections were stained either for β-galactosidase activity (X-gal) or neonatal MHC expression (NN-MHC). (C) Number of central nucleated fibers presented in the soleus and EDL in mice of different ages (1–9 mo) and in the same mice as in A. C, non- exercised mice; E, 5 d of exercise; R, exercise plus 5 d recovery. Note the increase in the number of the central nuclei in different muscles both with age and exercise. (D) Muscular endurance after exercises was analyzed on same group of mice. Des +/+ (white) and Des −/− (black). After 5 d of training, muscular endurance increased in the control group. This was transitory since when the animals were allowed to recuperate for 5 d, muscular endurance returned to the same value as before training. In contrast, in Des −/− mice there was no increase of endurance with exercise. Bars: (A and B) 100 μm.

Effect of exercise on muscles. (A) LacZ and NADH activity present on frozen sections of soleus and EDL from 5-mo-old Des +/− and Des −/− mice. Control, non-exercised mice; Exercise, 5 d of exercise. Recovery, exercise plus 5 d recovery. Note the strong expression of β-galactosidase (X-gal), NADH in the soleus (Sol) and EDL of exercise mice. (B) Frozen sections of the gastrocnemius muscles of Des−/− mice (Gas −/−) after 7 and 21 d of regeneration after injection of cardiotoxin. Sections were stained either for β-galactosidase activity (X-gal) or neonatal MHC expression (NN-MHC). (C) Number of central nucleated fibers presented in the soleus and EDL in mice of different ages (1–9 mo) and in the same mice as in A. C, non- exercised mice; E, 5 d of exercise; R, exercise plus 5 d recovery. Note the increase in the number of the central nuclei in different muscles both with age and exercise. (D) Muscular endurance after exercises was analyzed on same group of mice. Des +/+ (white) and Des −/− (black). After 5 d of training, muscular endurance increased in the control group. This was transitory since when the animals were allowed to recuperate for 5 d, muscular endurance returned to the same value as before training. In contrast, in Des −/− mice there was no increase of endurance with exercise. Bars: (A and B) 100 μm.