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. 1997 Apr 7;137(1):37–49. doi: 10.1083/jcb.137.1.37

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DIC and corresponding confocal immunofluorescence images of histone distribution in an E17 lens slice. The antibody recognizes an epitope common to histones H1, H2A, H2B, H3, and H4. (A) DIC image of the equatorial region of a lens slice showing the annular pad (ap) and superficial fibers. (B) Immunofluorescence image of the region shown in A. Note the strong labeling of nuclei in the annular pad and superficial fibers. (C) DIC image of fiber cells at the border of the OFZ. Fiber cell nuclei at various stages of disassembly are present, including those with marginalized (arrow) or condensed chromatin (arrowhead). (D) Immunofluorescence image of the region shown in C. During fiber cell denucleation, the distribution of histone proteins parallels that of the DNA (compare with Fig. 2 F ), becoming first marginalized (arrow) and then collapsing into condensed residual structures (arrowhead). Bars, (A and B) 50 μm; (C and D) 10 μm.