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. 1997 May 5;137(3):595–608. doi: 10.1083/jcb.137.3.595

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Stimulus-dependent exocytosis of mature β-granules releases an increased fraction of ProB from the islets of transgenic MPRdeficient mice. Islets from CD-MPR–deficient mice were pulse labeled and chased overnight in the absence of secretagogues to allow the labeled proinsulin and ProB to chase to their final destinations, before collecting sequential 30-min periods of unstimulated (−) and stimulated (+) secretion. See text for details. Secretion of labeled insulin and immunoprecipitable ProB were analyzed by SDS-PAGE and fluorography.