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. 1997 May 5;137(3):729–742. doi: 10.1083/jcb.137.3.729

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Entactin and type VII collagen codistribute with laminin-5 over regions of disorganized basement membrane and to both dermal and epidermal sides of blisters in α3-null skin. Frozen sections from neonatal skin were stained by double-label immunofluorescence with GoH3 monoclonal antibody against the α6 integrin subunit and antiserum against laminin-5 (A, E, I, and B, F, J, respectively), or by immunofluorescence with antisera against type VII collagen (C, G, and K) or entactin (D, H, and L). (A–D) Representative fields from wild-type skin. (E–H) Adjacent sections through a region of disorganized basement membrane in α3-null skin; arrows point to areas in the dermis, outside the basement membrane zone as defined by α6-staining (E) where basement membrane proteins are detected (F–H). (I–L) Adjacent sections through a blister in α3-null skin; arrowheads and arrows point to the dermal and epidermal sides of the blister, respectively. Bar, 50 μm.