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. 1997 Nov 17;139(4):1033–1046. doi: 10.1083/jcb.139.4.1033

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Full-length α-catenin can antagonize the endogenous induction of a dorsoanterior axis when expressed in dorsal blastomeres. 3.0 ng of either GFPαNcatCterm, which does not bind to β-catenin, or GFPαNcat, the full-length construct, were injected into both dorsal blastomeres of four-cell embryos. Embryos expressing GFPαNcat often develop the ventralized phenotypes illustrated here (B and D), with no anterior head structures present. Embryos expressing high levels of GFPαNcatCterm develop normally (A and C). Two stages are shown.