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. 1997 Nov 17;139(4):1033–1046. doi: 10.1083/jcb.139.4.1033

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Animal cap assays reveal the dissociated nature of blastomeres expressing dominant-negative α-catenin. (A) Animal caps in 1× MMR normally heal and involute after 1 h as shown in GFPαNcat-injected embryos. (B) αNcatNtermGFP-expressing animal caps fail to involute, and dissociated blastomeres disperse after 1 h. (C) Dissociated GFP-expressing animal caps reaggregate in 2 mM Ca²⁺, whereas in D animal caps expressing αNcatNtermGFP do not. mRNA was injected into the animal pole of both cells of two-cell embryos.