Figure 1.

(a) Integrating four methods in making up a database of hypothetical proteins viz., sequence based, structure based, association based and omic based. All the protein accessions were mined using a query (keywords hypothetical AND Homo sapiens) from NCBI searches (www.ncbi.nlm.nih.gov); for complete list of hypothetical proteins, please visit http://pc-dugong. ruc.dk:8080). (b) Interactors of B3BP are associated through different approaches (Please find the legend in different colors for different approaches). The network neighbourhood of B3BP (Marked in red; Accession #NP_438169) is shown as hypothetical when Entrez NCBI query is made. When this accession was queried using STRING, it facilitates in understanding how and what all the other proteins interacting with NP_438169 are doing in a network