Figure 2. Bactericidal Activity of Daily (5/7) R₁₀MZ, P₁₀MZ, and P₁₀HZ in Comparison to Standard Daily Therapy with R₁₀HZ in M. tuberculosis–Infected Mice.

Treatment began when the bacillary burden reached 7.45 ± 0.03 log₁₀ CFU per lung. After 10 wk of treatment and 3 mo of follow-up, the proportion of mice that were lung culture–positive was 100% and 53% for the R-containing regimens (R₁₀HZ and R₁₀MZ, respectively) and only 13% and 0% for the P-containing regimens (P₁₀HZ and P₁₀MZ, respectively) (data not shown in Figure). H, isoniazid; M, moxifloxacin; Z, pyrazinamide; R, rifampin; P, rifapentine.