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. 1998 Feb 9;140(3):659–674. doi: 10.1083/jcb.140.3.659

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Movements of several representative transporting vesicles of GAP-43 (A), and synaptophysin (B, tubulovesicular organelles, and C, large globular vesicles that colocalize with FM1-43 or Texas red–dextran). Anterograde movement (from the cell body to the periphery) was set as plus direction. The net translocation (μm) of each vesicle from the starting point was plotted against the time (s). Intervals between the frames were 3.3 s. Comparison with the tubulovesicular organelles that transport either GAP-43 (A) or synaptophysin (B) revealed that the large globular vesicles often change the direction of the movement (C). Nevertheless, the large globular vesicles have a tendency to move retrogradely.

Movements of several representative transporting vesicles of GAP-43 (A), and synaptophysin (B, tubulovesicular organelles, and C, large globular vesicles that colocalize with FM1-43 or Texas red–dextran). Anterograde movement (from the cell body to the periphery) was set as plus direction. The net translocation (μm) of each vesicle from the starting point was plotted against the time (s). Intervals between the frames were 3.3 s. Comparison with the tubulovesicular organelles that transport either GAP-43 (A) or synaptophysin (B) revealed that the large globular vesicles often change the direction of the movement (C). Nevertheless, the large globular vesicles have a tendency to move retrogradely.