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. 1998 Feb 9;140(3):603–616. doi: 10.1083/jcb.140.3.603

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Model for the ARF6:GTP/GDP cycle in CHO cells. Nucleotide exchange on ARF6 drives the transport and subsequent fusion of recycling vesicles with the plasma membrane. Hydrolysis of bound GTP at the cell surface allows the internalization of ARF6 via membrane vesicles inaccessible to HRP or the release of ARF6 from the membrane into the cytosol. Cytosolic ARF6 would have to be recruited back onto the recycling compartment (R.C.) for another nucleotide cycle to ensue.