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. 1997 Dec 1;139(5):1349–1360. doi: 10.1083/jcb.139.5.1349

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Neutrophils can migrate in opposite directions in the same field of overlapping chemoattractant gradients. The migratory behavior of neutrophils placed in IL-8 (originating in a well below the picture) and LTB4 (originating in a well above the picture) was recorded by time-lapse video microscopy. The image shows cells at the leading edge of each population 90 min after the start of the assay, when each population is nearing a common point between the starting wells. Arrows indicate the migration paths of several representative cells over the next 15 min. Most cells that started at the IL-8 source migrate towards the LTB4 source and vice versa; occasionally, a cell is observed to change directions (i.e., cell indicated by *).