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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Sep 15;17(23):6638–6642. doi: 10.1016/j.bmcl.2007.09.048

Table 1.

Anti-tuberculosis activity and in vitro data of nitrofuran compounds with isoxazoline linkage (NT:Not Tested)

Compd. Structure M. tb MIC90 (μg/mL) Solubility (mg/L)
MW (g/mol) cLogP %Protein bound Microsomal stability % remaining@ 90min Log10 Reduction in M. tb CFU in Lung vs. untreated controls± SEM
pH 6.0 pH 7.4
5 graphic file with name nihms35151t1.jpg 0.0001 NT NT 442.5 3.99 NT NT NT
6a graphic file with name nihms35151t2.jpg 0.00005 3.34 0.236 432.5 4.29 99.9 31 0.64 ± 0.21
6b graphic file with name nihms35151t3.jpg 0.0001 4 3.6 414.4 3.28 99.0 12 0.59 ± 0.22
6c graphic file with name nihms35151t4.jpg 0.0002 27.7 20 427.5 2.58 97.3 26 0.83 ± 0.20
7 graphic file with name nihms35151t5.jpg 0.00156 0.017 0.014 341.4 4.48 98.8 6 NT
Isoniazid graphic file with name nihms35151t6.jpg 0.025 NT NT 137.1 −0.67 NT NT 3.98 ± 0.26