Fig. 2. Auditory but not vestibular dysfunction in deaf5/deaf5 mutant mice.
A. Auditory brainstem response (ABR) recordings show normal wave patterns and thresholds in +/deaf5 heterozygous control mice, but no evoked responses at all in deaf5/deaf5 homozygous mutant mice tested at 4 weeks of age. ABRs for broad-band click stimuli are shown here, but similar results were obtained for 8 kHz, 16 kHz, and 32 kHz pure tone stimuli. B. Vestibular evoked potential (VsEP) recordings of +/deaf5 control mice and deaf5/deaf5 mutant mice show nearly identical response amplitudes and threshold levels. Diagnostic peaks are indicated by arrowheads.