Figure 1.

Inhibition of atherosclerosis by treatment with candesartan. Male apoE-deficient mice were fed either a standard chow diet (Low Fat) or a high fat diet for 4 months. Some animals were treated with candesartan for the entire 4 month experimental period. Panel A shows blood pressure measurements obtained using the tail cuff technique. Panel B contains representative en face preparations of the descending aortas from animals from each of the 3 experimental groups. Note the marked inhibition of atherosclerosis in the animals fed the high fat diet and treated with candesartan. Panel C summarizes the mean atherosclerotic lesion area for all 3 experimental groups. Eight -12 animals were included in each experimental group. * = P <0.01