Figure 2.

Lack of Inhibition of atherosclerosis by treatment with amlodipine. Male apoE-deficient mice were fed a high fat diet for 4 months. Some animals were treated with amlodipine for the entire 4 month experimental period. Panel A shows blood pressure measurements obtained using the tail cuff technique. Note that the blood pressure reduction was similar to that seen with candesartan treatment. Panel B contains representative en face preparations of the descending aortas from animals from both of the experimental groups. Note the lack of effect of amlodipine on atherosclerotic lesion area. Mean data are resented in panel C. Eight -12 animals were included in each experimental group. * = p <0.01