Figure 3.

Angiotensin II receptor blockade halts atherosclerotic disease progression in animals with established atherosclerosis. Male apoE-deficient mice were fed a high fat diet for 6 months. Some animals were treated with candesartan for the months 5 and 6. Panel A shows blood pressure measurements obtained using the tail cuff technique. Panel B contains representative en face preparation from both treatment groups. Note that treatment with candesartan resulted in a halt in the progression of atherosclerosis. Mean data are presented in panel C. Eight - 10 animals were included in each experimental group. * = p <0.01