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. 1997 Aug 11;138(3):657–669. doi: 10.1083/jcb.138.3.657

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KIF2 suppression alters the distribution of β_gc, but not of synaptophysin, GAP-43, or synapsin I in NGF-treated PC12 cells. (A–D) Double immunofluorescence micrographs showing the distribution of β_gc (A and C), synaptophysin (B), and GAP-43 (D) in NGF-differentiated PC12 cells treated with a KIF2 antisense oligonucleotide (ASKF2a, 5 μM). Note that while β_gc completely disappears from growth cones (arrows), synaptophysin and GAP-43 remain highly concentrated at neuritic tips. (E and F) Double immunofluorescence micrographs showing the distribution of tyrosinated α-tubulin (E) and synapsin I (F) in NGF-differentiated PC12 cells treated with ASKF2a (5 μM). Note that synapsin I is highly concentrated at neuritic tips. For these experiments, cells were treated with oligonucleotides as described in Fig. 7. Bar, 10 μm.