Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1997 Aug 11;138(3):657–669. doi: 10.1083/jcb.138.3.657

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

(A and B) Double immunofluorescence micrographs showing the distribution of β_gc (A) and APP (B) in NGF-differentiated PC12 cells treated with the KIF2 antisense oligonucleotide ASKF2b (5 μM). Note that while β_gc completely disappears from growth cones (arrowheads) APP remains highly concentrated at neuritic tips. (C and D) Double immunofluorescence micrographs showing the distribution of β_gc (C) and APP (D) in NGF-differentiated PC12 cells treated with the KHC antisense oligonucleotide -11/ 14 hkin (50 μM). Note that while this treatment does not affect the growth cone localization of β_gc, it dramatically decreases APP immunofluorescence at neuritic tips. For these experiments, cells were treated with antisense oligonucleotides as described in Fig. 7. Bar, 10 μm.