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. 1997 Aug 11;138(3):671–680. doi: 10.1083/jcb.138.3.671

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Proteolytic processing of APP_FL. The diagram depicts APP fragments generated by both the α- and β-secretase pathways. A large, secreted ectodomain called APPα is generated by the putative α-secretase(s) that cleaves APP_FL within the Aβ domain. A second cleavage by the γ-secretase(s) releases a subfragment of Aβ known as p3. Alternative cleavage by the β-secretase(s) generates a similarly large ectodomain fragment known as APPβ. After the subsequent γ-secretase cleavage, Aβ is released. This schematic also shows the epitope location of the antibodies used in this study to identify the different proteolytic fragments.