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. 1998 Feb 23;140(4):947–959. doi: 10.1083/jcb.140.4.947

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Electron micrograph of ACE cells cultured on basal-lamina type extracellular matrix after a 24-h treatment with VEGF. (a) ACE cells form long thin cellular processes that are interrupted by numerous fenestrations (arrowheads). (b) The endothelial cell is still connected to the underlying extracellular matrix (M). Fenestrations (arrowheads) are bridged by thin diaphragms, which sometimes contain a central knob (arrows). (c) ACE cell with a cluster of fused vesicles, which are separated only by thin diaphragms with a central knob (arrows). Bars: (a and b) 0.2 μm; (c) 0.1 μm.