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. 1998 Feb 23;140(4):737–750. doi: 10.1083/jcb.140.4.737

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Localization of SRPK1 and SRPK2 in transfected HeLa tTA cells. FLAG-tagged SRPK1 (a and b) and SRPK2 (d and e) are localized in both the cytoplasm (represented in a and d) and the nucleus (represented in b and e). Predominant cytoplasmic signal was seen with GFP-SRPK1 (c) and GFP-SRPK2 (f), although some punctate nuclear population was visible (see c, for example). When viewed in different focal planes, signals in both the cytoplasm (g) and the nucleus (h) were evident, and the nuclear population (h) colocalized with the B1C8 antigen (i), a marker for nuclear speckles. A merged image appears yellow (j).