Fig. 1.
s.c. injection of VEGF Trap into SCID mice at different doses reveals different levels of circulating free VEGF Trap but similar levels of circulating mouse VEGF–VEGF Trap complex. At all doses ranging from 1 mg/kg (A) to 25 mg/kg (D), a steady-state level of VEGF–VEGF Trap complex is achieved, which plateaus at ≈1 μg/ml. Dose-dependent levels of free VEGF Trap are observed as follows: 1 mg/kg to 10 μg/ml Cmax falling below complex levels at 4 days (A); 2.5 mg/kg to 20 μg/ml Cmax falling below complex levels at 7 days (B); 10 mg/kg to 80 μg/ml Cmax falling below complex levels at 9 days (C); and 25 mg/kg to 200 μg/ml Cmax falling below complex levels at 17 days (D). The half-life of VEGF Trap is ≈2 days at doses >2.5 mg/kg. (n = 6 for each dose.)