Skip to main content
. 2007 Nov 13;104(47):18363–18370. doi: 10.1073/pnas.0708865104

Fig. 6.

Fig. 6.

Circulating free VEGF Trap and human VEGF–VEGF Trap complex levels are very similar in the plasmas of AMD and cancer patients. (A and B) Patients with AMD received a single i.v. bolus of VEGF Trap at 0.3, 1, or 3 mg/kg, and free VEGF Trap and complex levels were measured at 2 and 4 h and 1, 4, 8, and 15 days (n = 7, 0.3 mg/kg; n = 7, 1 mg/kg; n = 5, 3 mg/kg). (C and D) Patients with cancer received a single i.v. bolus of VEGF Trap at 0.3, 1, 2, 3, or 4 mg/kg, and free VEGF Trap and complex levels were measured at 1, 2, 4, and 8 h and 1, 2, 4, 7, 10, and 14 days (n = 3, 0.3 mg/kg; n = 7, 1 mg/kg; n = 6, 2 mg/kg; n = 5, 3 mg/kg; n = 7, 4 mg/kg). (E) Complex levels in AMD patients at 15 days and cancer patients at 14 days were plotted against the different doses revealing an almost exact overlap. Dotted lines denote the steady-state circulating levels of VEGF–VEGF Trap complex in AMD and cancer patients.