Fig. 3.

Model for the evolution of the FLNA–EMD region. (A) Generation of an inverted duplication (filled arrows) in a common ancestor of eutherians and continuous NAHR between the duplications led to the homogenization of the duplications by gene conversion and the recurrent inversion of the locus. (B) Remodeling of the ancient duplications by the conversion of insertions (gray boxes) and deletions. (C) Long-tract gene conversion (25) resulted in the expansion of the duplications (gray arrows). DSB, double-strand break.