Table 5.

Predictive values for combination markers to identify each of the three clusters

Positive, no.	κ coefficient	Specificity, %	Sensitivity, %	PPV, %	NPV, %
CIMP 1 (BRAF-Mutation, hMLH1-Meth, Timp3-Meth, MINT1-Meth, and RIZ1-Meth)
2 of 5	0.80	95	86	83	96
3 of 5	0.81	99	77	94	94
CIMP2 (KRAS-Mutation, MINT27-Meth, MINT2-Meth, MINT31-Meth, and Megalin-Meth)
2 of 5	0.40	60	84	56	86
3 of 5	0.30	45	89	50	87
CIMP Negative (p53-Mutation, MINT27-Unmeth, MINT2-Unmeth, MINT31-Unmeth, MINT1-Unmeth)
2 of 5	0.55	61	100	62	100
3 of 5	0.72	76	100	73	100