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Function and mechanism of the NBDs of SUR1. (A) Role of the KATP channel in glucose-stimulated insulin secretion. (B) Comparison of the amino acid sequences of the Walker A motifs (consensus: GXXXXGKT/S) in the NBDs of various ABCC-family proteins. Residues equivalent to SUR1-R1380 are in boldface. MRP, multidrug resistance-related protein; CFTR, cystic fibrosis transmembrane conductance regulator. (C) The SUR1 ATPase catalytic cycle. BeF, beryllium fluoride (BeF3− and BeF42−).
