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ATPase activity of SUR1-NBD2 under various conditions. ○, wild-type; ●, R1380C; and ▴, R1380L. (A) ATP activity as a function of ATP concentration. (B) Concentration dependence of MgADP inhibition of ATPase activity (at 1 mM MgATP). (C) Concentration dependence of BeF inhibition of ATPase activity (at 1 mM MgATP).
