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Defective intracellular trafficking of cog Tg in COS cells. COS-7 cells were either untransfected or transiently tranfected with Tg cDNAs as described in Materials and Methods. By Western blot analysis, unlike the control Tg, a protein encoded by the cog Tg cDNA could be found intracellularly but was secreted into the overnight collection medium at levels below the limits of detection.
