Skip to main content
. 2008 Jan;17(1):183–186. doi: 10.1110/ps.073217708

Figure 1.

Figure 1.

(A) Loop extension-induced REFERs for CI2 (●), SH3S19P20 (□), and SH3N47D48 (◊) (Ladurner and Fersht 1997; Viguera and Serrano 1997). The continuous lines are linear fits to the data. The dashed lines correspond to αLoop-values of 0 and 1 and are shown as a reference. (B) Observed versus predicted effects of loop extension on ΔG 0 for CI2 (●), SH3S19P20 (□), and SH3N47D48 (◊) (Ladurner and Fersht 1997; Viguera and Serrano 1997). The continuous lines are linear fits to the data. The dashed line has a slope of 1 and corresponds to a negligible amount of residual structure in the unfolded state. The predicted ΔΔG 0-value for the addition of n residues to an unstructured loop of N residues is ΔΔG 0 = 1.5 · RT · ln(1 + n/N) (Jacobson and Stockmeier 1950). N = 7 and n = 2–6 for CI2; N = 3 and n = 2–8 for both SH3 domains.