Figure 4.

Frequency and severity of insulitis and diabetes. Insulitis in 7-week-old female (A) and 10-week-old male (B) tg(+) (filled bar) and non-tg(+) (empty bar) mice. (A) tg(+), n = 6; non-tg(+), n = 7. (B) Non-tg(+), n = 10; tg(+), n = 10. Severity of insulitis on a scale of − to ++++ was assessed as described in the text. Incidence of spontaneous diabetes in female (C) and male (D) tg(+) and non-tg(+) mice. Blood glucose levels were measured weekly starting from 10 weeks of age. ⧫ and □ represent weekly assessments of tg(+) mice and non-tg(+) littermates, respectively.