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. 1998 Aug 18;95(17):10094–10099. doi: 10.1073/pnas.95.17.10094

Figure 4.

Figure 4

T cells recognize variations in the conformations of the MHC class II-peptide complexes. (A) D10 T cells that recognize I-Ab with various undefined peptides proliferate in response to invariant chain negative L cells transfected with WT Ab and Ab-mCLIP but not Ab-pEα cDNA. (B) D10 reactivity to WT or Ab-mCLIP expressed by Ii-negative L cells can be blocked by mAb 25-9-17. YAe mAb was used as negative control. (C) D10 responds well to stimulation with Ab presented by spleen cells from normal B6 and Ii-deficient animals. Nonstimulated D10 cells incorporated less than 200 cpm.