Table 1.

CNS pathology of mice treated with GGF2 via the s.c. or i.v. route

Treatment	Pathology	Clinical score*
		8 dpt	19 dpt	42 dpt
Vehicle	Inflamm.	3.4*	2.5	2.3
	Demyel.	2.6	2.6	1.9
2.0 mg GGF2 s.c.	Inflamm.	1.1	2.2	1.8
	Demyel.	0.4	1.6	0.7
2 mg GGF2 i.v.	Inflamm.	2.2	2.4	†
	Demyel.	1.0	1.7	†
1 mg GGF2 i.v.	Inflamm.	3.0	2.3	2.4
	Demyel.	2.2	1.9	2.2

^*Animals scored on scale of 0–5. Each score represents the mean of 18 slides per animal from 9 levels of the neuraxis. 

^†No survivors in this i.v. group. Lower dosing via the i.v. route and s.c. administration at all dose levels tested did not result in any deaths.