Figure 3.

Inhibitory effect of BO-653 on the atherosclerosis of high-fat-fed mice. Female mice were maintained on a high-fat diet containing 0.5% of the compound for 28 weeks. (a and b) Serial changes of VLDL + LDL concentration (a) and HDL concentration (b). The lipoprotein concentrations were evaluated as cholesterol concentrations of respective fractions by gel-permeation chromatography. (c) Representative cross sections of aortic valvesin hearts of high-fat-fed mice. Atherosclerotic lesions are shown by arrows. (×100.) (d) Effect of BO-653 on atherosclerotic lesions in high-fat-fed mice. All results are shown as mean ± SE, n = 5 (normal diet group) or 10 or 11. ∗, P < 0.05; ∗∗, P < 0.01.