Table 1.

Plasma cholesterol, VLDL + LDL, and HDL levels and LDL oxidizability in WHHL rabbits

Measurement	WHHL rabbits
	Control	Probucol 1%	BO-653		Normal rabbits
			0.5%	0.2%
Plasma cholesterol, mg/dl
Total
Start	951  ± 59	984  ± 91	972  ± 94	970  ± 92	—
Six months	751  ± 61	640  ± 88	679  ± 84	793  ± 52	49  ± 5*
VLDL + LDL cholesterol	723  ± 67	630  ± 78	608  ± 70	747  ± 47	11  ± 0*
HDL cholesterol	8.6  ± 0.6	5.6  ± 0.3	8.5  ± 1.2	10.4  ± 0.4	38  ± 6*
TBARS content in LDL, nmol/mg protein
Unincubated	1.5  ± 0.3	1.2  ± 0.2	1.0  ± 0.3	1.4  ± 0.2	—
Incubated with Cu2+	83.3  ± 6.2	3.5  ± 0.3*	2.4  ± 0.4*	3.4  ± 0.1*	—
Incubated with lipoxygenase	37.9  ± 2.3	5.5  ± 0.5*	2.0  ± 0.4*	10.5  ± 5.3*	—

The lipoprotein concentrations were evaluated as cholesterol concentrations of respective fractions by gel-permeation chromatography. LDL samples were prepared individually from the plasma samples and the oxidizability was evaluated as the TBARS content generated by incubating for 24 hr with Cu²⁺ or lipoxygenase. All results are shown as mean ± SE, N = 4 or 5. 

^*P < 0.01 compared with control.