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Bar graph shows Mac-1-dependent FGN binding, uptake, and degradation by rabbit monocytes in the presence of M1/70 (1–5 μg/ml) or isotype-matched control mAb M5/114 (5 μg/ml). M1/70 inhibited FGN turnover in a concentration-dependent manner. The effect of mAb treatment is depicted as the percentage of control nonantibody-treated monocyte FGN turnover present in antibody-treated monocytes. ∗, P < 0.01 compared with control or M5/114.
